|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD1d was detected by flow cytometric analyses on leukemic cells of all B-CLL cases studied (n = 38) and was expressed at higher density on cells carrying unmutated immunoglobulin variable region (IgV) genes.
|
14961579 |
2004 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Aggressive cases with unmutated IGHV genes (U-CLL) displayed significantly higher EZH2 expression compared to indolent CLL cases with mutated IGHV genes (M-CLL); furthermore, in U-CLL EZH2 expression was upregulated with disease progression.
|
27191993 |
2016 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A unique microRNA expression signature composed of 13 genes (of 190 analyzed) differentiated cases of CLL with low levels of ZAP-70 expression from those with high levels and cases with unmutated IgV(H) from those with mutated IgV(H) .
|
16251535 |
2005 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In CLL, miR-223 expression decreased significantly with progression from early to advanced clinical stages and was significantly lower in patients with elevated β(2)-microglobulin, unmutated immunoglobulin variable heavy chain (IgVH) gene or with disease progression or death.
|
22145958 |
2012 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Positive mutation status was found to be associated with unmutated IGHV and ZAP70 expression, which are well-known poor prognosis markers in CLL.
|
25595892 |
2015 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Measuring ZAP-70 methylation status at C-334 is a simple and reproducible method for predicting prognosis in CLL, which is closely associated with ZAP-70 expression and IgVH gene mutational status.
|
16079107 |
2005 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In recent decades, numerous prognostic markers, such as immunoglobulin variable region heavy-chain (IgVH) mutational status, ZAP-70 and the expression of CD38 on leukaemic cells were introduced to screen for patients likely to have progressive course of B-CLL bearing the potential to facilitate risk-adapted treatment strategies.
|
19247976 |
2009 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The most frequently used IGHV gene was IGHV3-7 (12.6%) followed by IGHV3-30 (11.4%), IGHV3-48 (9.2%), IGHV4-39 (6.9%), and IGHV1-8 (6.9%) genes, which taken together comprised nearly half of the IGHV genes expressed in the Iranian CLL patients.
|
19824994 |
2009 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TAp63 mRNA levels were higher in CLL with unmutated IGHV.
|
24117128 |
2013 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present series, 201 (21.9%) of 916 patients with CLL expressed IGHV genes that belonged to 1 of 48 different subsets of sequences with stereotyped heavy chain (H) CDR3.
|
16985177 |
2007 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Statistical analysis identified a significant correlation between ARSD and IGVH; however, both ARSD protein level and IGVH were independently associated with the need for therapy of CLL patients.
|
22820137 |
2012 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was showed that LPL expression correlates with IgVH mutational status and other clinical or laboratory prognostic factors, and might be applied for the assessment of prognosis in patients with CLL.
|
18616755 |
2009 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We developed a flow cytometry assay for ZAP-70 protein expression and investigated its concordance with ZAP-70 mRNA expression, IgVH gene mutational status, and clinical outcome in 167 patients with CLL.
|
14726163 |
2004 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The high frequency of the 17.109-associated idiotype and the V kappa RF gene in CLL suggests that the disease may arise from B lymphocytes that express a restricted set of inherited immunoglobulin variable-region genes with little or no somatic mutation.
|
3106980 |
1987 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CLL cells that expressed ζ-chain-associated protein of 70 kDa (ZAP-70) or that used unmutated immunoglobulin heavy chain variable (IGHV) genes, each had a median expression level of miR-150 that was significantly lower than that of ZAP-70-negative CLL cells or those that used mutated IGHV genes.
|
24787006 |
2014 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ZAP-70 methylation 223 nucleotides downstream of transcription start (CpG+223) predicts outcome in chronic lymphocytic leukemia (CLL), but its impact relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain.
|
24868078 |
2014 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.
|
29953583 |
2018 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Peptides that bind specifically to an antibody from a chronic lymphocytic leukemia clone expressing unmutated immunoglobulin variable region genes.
|
23922242 |
2013 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of S1P2, which controls B-cell homeostasis, is also impaired in CLL B cells but independently of the IGHV mutational status.
|
23033271 |
2012 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Most investigated drugs demonstrated similar activity in CLL cells from patients with unmutated and mutated IGHV genes as well as in CLL cells vs. PBMC.
|
19245531 |
2009 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we evaluated the reactivity of a panel of different CLL recombinant antibodies (rAbs) encoded by the most commonly expressed IGHV genes with a panel of selected viral and bacterial pathogens.
|
22234695 |
2012 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVH gene status in 205 patients with chronic lymphocytic leukemia (B-CLL).
|
12149195 |
2002 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IGHV gene mutational status and LPL/ADAM29 gene expression as clinical outcome predictors in CLL patients in remission following treatment with oral fludarabine plus cyclophosphamide.
|
19340428 |
2009 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The number and pattern of somatic mutations differ in tumors with unmutated and mutated IGHV, extending at the genomic level the clinical differences observed in these two CLL subtypes.
|
24014293 |
2013 |
|
LOC102724971
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, and zeta-associated protein 70 (ZAP-70) expression levels have independent prognostic relevance in chronic lymphocytic leukemia (CLL); however, their concordance is variable.
|
19717645 |
2009 |